Expeditions: Conquistador is set during the Age of Exploration. The player's goal is to mount an expedition from Spain to Hispaniola and Mexico, amassing gold and influence while building and sustaining a strong expedition force. The game concludes with the player's return to Spain. During the course of the expedition, the player has the opportunity to influence the fate of the explored lands. The game is set in an alternate history that allows the player's choices to diverge from historical events.