At the beginning of the game, Fone Bone, Phoney Bone, and Smiley Bone have been run out of their hometown of Boneville due to one of Phoney Bone's schemes of robbing. They find themselves lost in the desert with only a mysterious map to help them figure out where they are. The cousins are separated when a swarm of locusts descends upon them. The player must then help Fone Bone and Phoney Bone explore a mysterious valley to find their cousin Smiley. In the process, they make friends with a tiny bug named Ted, a beautiful girl named Thorn, her energetic grandmother Gran'ma Ben, and a trio of playful 'possum kids. The sinister rat creatures are always on their tails but the enigmatic Red Dragon keeps them at bay.
This article uses material from the Wikipedia article Bone: Out from Boneville, https://en.wikipedia.org/wiki/Bone:_Out_from_Boneville, which is released under the Creative Commons Attribution-Share-Alike License 3.0, https://creativecommons.org/licenses/by-sa/3.0/.